DNA is seen as a natural form of information storage, and cells are interpreted as living programs that have been successfully replicating code for ages. Both DNA and cells are increasingly used as wetware computers — computers made of organic material. A chronological, retrospective look at the developments that have lead to today’s wetware computers takes us from Alfred James Lotka’s ›Elements of Physical Biology‹ (1925) to Claude Shannon’s ›Algebra for Theoretical Genetic‹ (1940), George M. Church’s et al. ›DNAStorage‹ (2012), and Jerome Bonnet’s et al. ›Transcriptor‹ which was developed in 2013 and functions as the genetic equivalent to an electronic transistor. These burgeoning developments are not devised to replace conventional in-silico computing but to create living computers inside animals and humans detecting diseases and toxic threats.